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Veeresh Babu, D.
- Pharmacological Evaluation of Trichilia connaroides Bark for Analgesic and Anti-inflammatory Activity in Experimental Animal Models
Authors
1 Department of Pharmacology, Karavali College of Pharmacy, Mangalore, IN
2 Department of Pharmacognosy, Karavali College of Pharmacy, Mangalore, IN
Source
Asian Journal of Pharmaceutical Research, Vol 5, No 3 (2015), Pagination: 138-144Abstract
The present study was designed to evaluate the analgesic and anti-inflammatory activity of "Trichilia connaroides" bark using different animal models. Analgesic activity was evaluated by using various two animal models namely, Writing Test using acetic acid in mice and Hot Plate Method. The degree of analgesic activity was determined by the number of wriths was recorded for each animal in Writing Test using acetic acid in mice model and the delay in reaction time for of each animal when place in hot plate maintained at 55±0.10c is recorded in Hot Plate Method. Anti-inflammatory activity was evaluated using Formalin induced paw edema model, Croton oil ear edema in rats. Trichilia connaroides bark ethanolic extracts produced significant analgesic activity in both Hot plate and acetic acid induced writhing models in mice. In hot plate method percentage increase in reaction time was determined where as in acetic acid induced writhing model percentage decrease in writhings was determined. Evaluation of anti inflammatory activity was done by Formalin induced paw edema model, Croton oil ear edema model. In Formalin induced paw edema model mean change in paw volume and percentage protection were calculated. In croton oil ear edema model the difference between untreated ear and treated ear were determined which indicated degree of inflammatory edema. The study revealed that the "Trichilia connaroides" bark possess a significant analgesic and anti-inflammatory activity.Keywords
"Trichilia connaroides" Bark, Writing Test Using Acetic Acid, Hot Plate Method, Formalin Induced Paw Edema Model, Croton Oil Ear Edema in Rats.- Studies on Anti-Depressant and Anti-Inflammatory Activities of Curcuma aromatica Rhizome in Experimental Animal Models
Authors
1 Department of Pharmacology, Karavali College of Pharmacy, Mangalore, IN
2 Department of Pharmacognosy, Karavali College of Pharmacy, Mangalore, IN
Source
Asian Journal of Pharmaceutical Research, Vol 6, No 2 (2016), Pagination: 79-86Abstract
The present study was designed to evaluate the antidepressant and anti-inflammatory activity of "Curcuma aromatica" oil and "Curcuma aromatica" extract using different animal models. Antidepressant activity was evaluated by using various animal models. The degree of antidepressant activity was determined by measuring the immobility time in forced swim test and tail suspension tests. Anti-inflammatory activity was evaluated using Carrageenan induced paw edema model. Animals treated with all three doses of CAO (250,500 and 750mg/kg) witnessed a decrease in their immobility times in FST and TST which was significant when compared with control. Similarly, animals treated with Imipramine (15mg/kg), as expected showed a significant decrease in the immobility time.
Carrageenan induced paw edema model was employed to evaluate the anti-inflammatory activity of ethanolic extract of "Curcuma aromatica". Carrageenan induced paw edema model uses change in paw volume of control, test, and standard respectively to find out percentage inhibition of edema .The study revealed that the "Curcuma aromatica" rhizome oil possess a significant antidepressant and anti-inflammatory activity.
Keywords
Curcuma aromatica Oil, Forced Swim Test, Tail Suspension Test, Anti Depressant, Carrageenan Induced Paw Edema Model.- A Study on Antidepressant Activity of Medha gulika-a Polyherbal Formulation in Experimental Animal Models
Authors
1 Department of Pharmacology, Karavali College of Pharmacy, Mangalore, IN
2 Department of Pharmacognosy, Karavali College of Pharmacy, Mangalore, IN
Source
Asian Journal of Pharmacy and Technology, Vol 5, No 2 (2015), Pagination: 115-121Abstract
According to WHO, depression is a common mental disorder, characterized by sadness, loss of interest or pleasure, feelings of guilt or low self-worth, disturbed sleep or appetite, feelings of tiredness and poor concentration. The objective of the proposed study was to investigate the therapeutic potential of poly herbal formulation Medhagulika on Depression in different animal models. Evaluation of antidepressant activity was done by using 3 doses of Medhagulika (53.85, 102.77 and 154.16mg/kg) in vivo models. Animals treated with all three doses of Medhagulika witnessed a decrease in their immobility times in FST and TST which was significant when compared with control. Similarly, animals treated with imipramine (15mg/kg), as expected showed a significant decrease in the immobility time. In learned Helplessness Test, The Medhagulika treated mices showed significant increase in avoidance response and decreased in escape failure in response to shock treatment. Open field test utilizes behavioural changes in rodent exposed to novel environments and is used to confirm the observed antidepressant effect is not due to stimulation of general motor activity.Keywords
Medhagulika, Forced Swim Test, Tail Suspension Test, Anti Depressant, Open Field Test.- Studies on Memory Enhancing Property of Bravobol-A Polyherbal Formulation in Experimentally Induced Alzheimers Disease in Experimental Animals
Authors
1 Department of Pharmacology, Karavali College of Pharmacy, Mangalore, IN
2 Department of Pharmacognosy, Karavali College of Pharmacy, Mangalore, IN
Source
Asian Journal of Research in Pharmaceutical Sciences, Vol 5, No 2 (2015), Pagination: 1-8Abstract
In recent decades, it has become one of the principal pillars of a branch of science called cognitive neuroscience, an interdisciplinary link between cognitive and neuroscience. The objective of this to investigate the neuropsychological effect of a polyherbal formulation Bravobol on learning and memory processes in mice by elevated plus maze and Morris water maze model. Bravobol contains Evolvulus alsinoids (Shankhpushpi), Bacopa monnieri (Brahmi), Withania somnifera (Ashwagandha), Celastrus paniculatus (Malkangani) and Abhrak bhasma. Its effect (250, 500, and 750 mg/kg, p.o.) was tested on learning and memory processes. Activity of Bravobol on acquisition and retention was studied using elevated plus maze model (EPM) and spatial memory using Morris water maze model (MWM) in mice. The results were compared with the vehicle-treated group. Administration of Bravobol (250, 500 and 750 mg/kg, p.o) showed significant reduction in transfer latency in EPM and escape latency in MWM as compared to the control group. Bravobol may act as a memory enhancer formulation and may also be useful as a supportive adjuvant in the treatment of Alzheimers disease.Keywords
Polyherbal Formulation, Elevated Pluz Maze, Moriss Water Maze.- Studies on Anti-Depressant Activity of Perment-A Polyherbal Formulation in Experimental Animal Models
Authors
1 Department of Pharmacology, Karavali College of Pharmacy, Mangalore, IN
2 Department of Pharmacognosy, Karavali College of Pharmacy, Mangalore, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 8, No 2 (2016), Pagination: 45-54Abstract
Aim: The present study was designed to evaluate the anti depressant activity of a Poly herbal formulation "PERMENT" in experimental animal models.
Method: Anti depressant activity was evaluated in experimental different either sex animal models. The degree of anti depressant activity was determined by measuring the immobility time in Forced swim test and Tail suspension test, by counting the number of failure to escape and number of avoidance response in Learned helplessness test, Reserpine induced test the rectal temperature is determined and the number of passages of rodents through the hole from one chamber to another in Hole cross as a confirmatory test.
Result: Animals treated with all three doses of PERMENT (53.85, 102.77 and 154.16mg/kg) witnessed a decrease in their immobility times in FST and TST which was significant when compared with control. Similarly, animals treated with Imipramine (15mg/kg), as expected showed a significant decrease in the immobility time. In learned Helplessness Test, the PERMENT treated rats showed significant increase in avoidance response and decreased in escape failure in response to shock treatment. In Reserpine Induced Test the initial rectal temperature is determined by electronic thermometer. Hole cross test utilizes the number of passages of rodents through the hole from one chamber to another.
Conclusion: The study revealed that the "PERMENT" possess a significant anti depressant activity.
Keywords
PERMENT, Forced Swim Test, Tail Suspension Test, Reserpine Induced Test, Hole Cross Test.- Evaluation of Anti-Diabetic and Anti-Inflammatory Activities of Ethanolic Extract of whole Plant of Inula racemosa
Authors
1 Department of Pharmacology, Karavali College of Pharmacy, Mangalore, IN
2 Department of Pharmacognosy, Karavali College of Pharmacy, Mangalore, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 7, No 3 (2015), Pagination: 129-134Abstract
The present study was designed to evaluate the antidiabetic and anti-inflammatory activity of ethanolic extract of whole plant of "Inula racemosa" using different animal models. Antidiabetic activity was evaluated by using various two animal models. The alloxan induced diabetes method and streptozocin induced diabetes method along with biochemical parameters like SALP, SGPT, SGOT, Triglycerides, Total proteins were employed to investigate antidiabetic potential of Inula racemosa. Anti-inflammatory activity was evaluated using formalin induced paw edema model and croton oil ear edema model. Carrageenan induced paw edema model uses change in paw volume of control, test, and standard respectively to find out percentage inhibition of edema. The study revealed that the whole plant of "Inula racemosa" possess a significant anti-diabetic and anti-inflammatory activity.Keywords
Inula racemosa, Alloxan Induced Diabetes Method, Streptozocin Induced Diabetes Method, Formalin Induced Paw Edema Model, Croton Oil Ear Edema Model.- Studies on Memory Enhancing Property of Sumenta-A Polymherbal Formulation in Experimentally Induced Alzhiemers Disease in Experimental Animals
Authors
1 Department of Pharmacology, Karavali College of Pharmacy, Mangalore, IN
2 Department of Pharmacognosy, Karavali College of Pharmacy, Mangalore, IN